A pump-action shotgun that fires 12-gauge buckshot shells. Useful for low to medium range elimination of weak opponents, but lacks decent firepower to use against tougher enemies.
A side-by-side shotgun that is deadly against enemies at close range, but its high spread prevents long-range firing
A fully automatic submachine gun which is a modified replica of the original Thompson.
Handheld combat knife that can be used for slashing up weak enemies or as a stealth weapon.
Experimental grenade launcher
A chainsaw modified for combat. The weapon is extremely useful against most varieties of smaller foes, being more effective than the knife against multiple targets.
A very powerful long-ranged weapon which can be used for taking out targets from a distance.
An automatic cannon attached to a rotating wooden base. It will fire at Sam within its range. The cannonballs fired by this cannon are deadly.
A portable cannon and one of Serious Sam's iconic weapons.
A revolver with unlimited ammunition that deals decent damage but has a rather low rate of fire.
A handheld explosive which can deals instant death to any non-boss enemy within its range when detonated.
Functions just like the rotating cannon, but can only fire when the target moves past it.
Powerful energy weapon which deals 'slowlight' energy pulses towards targets, dealing high damage upon impact.
A very powerful, rapid firing automatic weapon that can annihilate hordes of weak enemies, but eats up ammunition quickly.
Experiential flamethrower which can burn up masses of weak enemies with flesh-penetrating flame. The flames can engulf even partially hidden targets.
Experimental rocket launcher that fires unguided armor-penetrating rockets.